ارزیابی سطح سرمی ویتامین A و E دربیماران مبتلا به سندرم روده تحریک پذیر و داوطلبان سالم در گرگان ، ۲۰۱۱

Abstract: 

Background and objective: Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases. It is a functional boweld is order characterized by chronic abdominal pain and change in bowel habits with no structural abnormality. The prevalence of this disease was estimated 10-20 percent in the world. However, the cause of IBS is still unknown. Because of malabsorption of the nutrients, vitamin may not be absorbed correctly; therefore, we aimed at evaluating the effectiveness of IBS on serum levels of vitamin and E.
Material & Methods: This case – control study was conducted on 94 IBS patients diagnosed by a gastroenterologist in Golestan province. The control group was selected from healthy people, who didn’t show any signs of digestive problems in past two years, matched by sex and age. Fasting blood samples were collected and the serum levels of vitamins A and E measured, using HPLC method.
Results: the mean of vitamin A in case and control groups is 57.0±۱۱۴٫۸ and 55.9±۲۳٫۸ mg/dl, and the mean of vitamin E in case and control groups is 0.50±۰٫۲۴ and 1.93±۱٫۸۶ mg/dl, respectively. The deficiency of vitamin A and E are 7.70 and 7.10 percent in males and 6.76 and 3.7 in females (P<0.05). In general, 1.1 percent of IBS patients show vitamin A deficiency and 93.6 percent of them vitamin E deficiency (P<0.05).
Conclusion: Conclusion: In this study, a significant decrease in vitamin E level is observed in patients with IBS. Due to antioxidant function of vitamin E, the deficiency of this vitamin can increase the oxidative factors leading to intestinal damages and it is expected to decrease the amount of vitamins, subsequently.