Abstract: Background and Objective: HER-2 (human epidermal growth factor receptor 2) is one such gene that can play a role in the development of breast cancer by making HER-2 proteins (receptorson breast cells). Normally, HER-2 receptors control breast cells grow and Division. HER-2 protein over expression is the cause of up to 20% of breast cancers. The phosphoinositide […]
Abstract: Background and Objective: Venous thromboembolism (VTE) is a common clinical condition with a mortality rate of 15-20%. Neutrophil to lymphocyte ratio (NLR) is known as an indicator in predicting clinical outcomes in patients with various diseases and malignancies. This study was conducted to determine the value of neutrophil to lymphocyte ratio in the prognosis […]
Abstract Background: Endothelial nitric oxide synthase, encoded by NOS3, produces an atheroprotective metabolite. The G894T, T-786C and 4a/4b variants of this gene associated with increased risk for coronary artery diseases (CAD) have been evaluated in different populations worldwide, and inconsistent results have been obtained. We investigated the association between these three polymorphisms and presence of CAD in Iranian […]
Abstract Background: Cardiovascular disease, such as atherosclerosis, is the leading cause of mortality worldwide. This study was aimed to compare the serum levels of copper, zinc, and iron in patients with ischemic heart disease and healthy individuals in order to achieve a better understanding of the impact of these elements on coronary artery stenosis. Materials and […]
ABSTRACT vitamin D. We aimed to assess serum vitamin D levels in high and low-risk populations for EC in Northern Iran. Methods:: This cross sectional study was conducted in Golestan province, Northern Iran. Based on the incidence rates of EC, the province was divided into high-risk and low-risk populations. A stratified cluster sampling method was […]
Abstract: Introduction: Nutritional status of patients with inflammatory bowel disease is estimated to be lower than optimal. This study was designed to compare the serum level of some trace elements in patients with ulcerative colitis (UC). Materials and methods: This cross-sectional study was performed in 2015-2016, on 60 recently diagnosed UC patients (30 with active UC and […]
Abstract It has been shown that fecal calprotectin can be used to evaluate mucosal inflammation better than using clinical indices and serum markers. The aim of this study was to assess the use of fecal calprotectin for evaluating the disease activity in 2 groups of patients with ulcerative colitis and a control group. The study […]
Abstract: Preeclampsia is the most common cause of prenatal and maternal mortality in the world. It is also the second most common cause of maternal death in Iran. Deficiency of some trace elements such as zinc, calcium and magnesium in pregnant women may be involved in preeclampsia. The aim of this study was to measure […]
ABSTRACT Background and Objectives: Recently, the incidence of breast cancer has increased drastically worldwide. Therefore, the identification of novel diagnostic biomarkers is essential for improving treatment outcomes and prognosis. Estrogen receptor (ER) and progesterone receptor (PR) are routinely available in breast cancer specimens. Semi-quantitative assessment of ER and PR is important for prognosis. Even with the development […]