کمبود ویتامین A و E سرم در بیماران مبتلا به بیماری التهابی روده

Abstract:

Chronic inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD), the etiologies of which are not certainly defined, and are hypothesized to be an interaction between environmental, genetic, and immunologic factors. 1 Recent studies show a gradually increasing rate of IBD in developing countries in Africa, South America, and Asia. 1 There has been a reported increase in the incidence and prevalence of IBD in the West during the past 50 years, 120-200/100000 for ulcerative colitis and 50-200/100000 for Crohn’s disease (CD). 1 Inflammatory bowel disease patients usually suffer from mal-absorption and mal-digestion, especially in the flare-up phase of the disease when increased requirement and decreased food intake are reported. Nutritional deficiency and malnutrition have been documented in IBD patients notably in CD, which may lead to adverse outcomes. 2 Vitamins B12, A, E, and D need to be monitored and supplemented. When a large amount of the small bowel is resected, all nutrients will be absorbed poorly. 3 This case-control study was designed to measure and compare serum levels of vitamins A and E between IBD patients and a healthy normal population in northeastern Iran. Due to the large differences in feeding habits in different areas, the aim of this study was to compare the levels of these vitamins in the patients and healthy cases. This case-control study was carried out from November 2011 to April 2012 in Golestan Province, Northern Iran. In this study, 94 pathologically confirmed IBD cases, and 94 healthy age and gendermatched controls with no gastrointestinal problems over the …