مقایسه سطح سرمی استرانسیوم و آنتیموان افراد سالم در مناطق پرخطر و کم خطر سرطان مری

Abstract

Background

It has been shown there is an upward trend for strontium (Sr) and antimony (Sb) levels from low-risk (LR) to high-risk (HR) areas of etiology of esophageal cancer in water, soil, and grains grown in Golestan province. In the present study, the serum levels of Sr and Sb were determined in healthy individuals living in these areas.

Methods

This cross-sectional study was performed on fasting blood serum of adult healthy individuals collected by cluster sampling. Subjects were divided into two groups, those living in either HR or LR areas. Strontium and antimony serum levels were measured using a graphite furnace atomic absorption spectroscopy.

Results

A total of 200 volunteers were enrolled from which 96 persons (48%) and 104 persons (52%) were from either HR or LR areas, respectively. The sex distribution was 40.9% male and 59.1% female, and the average age of enrolled people was 50.9 years. The average strontium levels were 30.44 ± ۴٫۰۵ and 30.29 ± ۳٫۷۴ μg/L in LR and HR, respectively. It also has been shown the average antimony levels were 15.21 ± ۳٫۴۰, ۱۴٫۸۱ ± ۳٫۱۷, ۱۵٫۱۳ ± ۳٫۶۲, and 15.07 ± ۳٫۶۲ μg/L in LR, HR, urban, and rural populations, respectively.

Conclusion

The serum levels of strontium and antimony were not significantly different in healthy adults living in high- and low-risk areas of esophageal cancer. However, the average antimony serum levels in Golestan Province were above the reference interval in different countries.

View Full Text: https://doi.org/10.1002/jcla.23269