تغییرات پلاسمائی اسید آمینه های شاخه دار در بیماران مبتلا به سرطان مری

BACKGROUND

Studies have indicated that branched amino acids play a crucial role in gene expression, protein metabolism, apoptosis, and restoration of hepatocytes and insulin resistance.  This study aimed to compare the plasma levels of branched-chain amino acids in patients with esophageal cancer and normal individuals.

METHODS

Plasma levels of leucine and isoleucine of 37 patients with esophageal cancer and 37 healthy adults were investigated by high-pressure liquid chromatography. Data analysis was performed using SPSS (version 16) software, and t test was used to compare the plasma levels of branched-chain amino acids in the two groups.

RESULTS

In the patients group, the mean age ± SD was 63±۱۳٫۶۴ years, and 21 (56.8%) individuals were male. In the control group, the mean age ± SD was 64.24±۱۳٫۰۸ years, and 21 (54.1%) individuals were male. Plasma levels of leucine (37.68±۱۰۵) and isoleucine (22.43±۵۹٫۱) in patients with esophageal cancer were significantly reduced (p value of isoleucine:0.007, and  leucine:0.0001).

CONCLUSIONS

In the present study, the plasma levels of branched-chain amino acids in patients with esophageal cancer had changed. Evidence suggests that branched-chain amino acids are essential nutrients for cancer growth and are used by tumors in various biosynthetic pathways as energy sources. Thus, studies in this field can be useful in providing appropriate therapeutic approaches.

View Full Text: http://10.34172/MEJDD.2021.203